Dardenne Prairie is a city in St. Charles County, Missouri, United States. The population was 11,494 at the 2010 census.

Dardenne Prairie is located southwest of O’Fallon upon Missouri Route N, just east of I-64. According to the United States Census Bureau, the city has a total Place of 4.92 square miles (12.74 km), all land.

Dardenne Prairie was originally a prairie region which began in the area near St. Peters and Elongated north of Dardenne Creek, almost to Peruque Creek. The Place was named after the stream.
In before documents the say appeared as Dardonne Creek, Darden Creek, Dardenne River, or Dardonne River. In Houck’s chronicles of 1908, Dardene River is with found.

Dardenne is said to be a tarnishing of the French “Terre d’Inde”, meaning the home of turkeys. Terre d’Inde actually translates to “Land of India”. “Turkey Land” on the extra hand in French is Terre des Dindons so the above relation is not plausible. A better report is that the pronounce was borrowed from the Dardenne family, early pioneers in the Mississippi Valley. “A Touissant Dardenne from Montreal, Canada, married Marie Francoise Lever, ‘veuve de feu Michal Vieu,’ at St. Anne de Fort Chartres, November 21, 1747. One of these Dardennes may have first camped and hunted upon this creek and thus solution it his name.” Touissant Dardenne, at Fort de Chartres on this matrimonial occasion, was still several hundred miles nearer to the creek he was supposed to have named than any extra person named Dardenne because no one by the name of Dardenne has ever owned land in St. Charles County, either below Spanish dominion or past the transfer. There is, of course, no defense why this creek, heavily wooded throughout its course, could not, by some French trapper, have been named Dardenne (or d’Ardenne in French) in memory of the Ardennes upon the river Meuse in French Flanders.