Creve Coeur is a city located in mid St. Louis County, Missouri, United States, a share of Greater St. Louis. Its population was 18,834 at the 2020 census. Creve Coeur borders and shares a ZIP code (63141) with the next to city of Town and Country. It is house to the headquarters of Drury Hotels, and Monsanto until its acquisition by Bayer in 2018.

The name crève cœur (French pronunciation: ​[krɛv kœʁ], “heartbreak”) is said to derive from Creve Coeur Lake. According to the city’s website, the symbol goes that the lake “formed itself into a broken heart” after an Indian princess’s unrequited love for a French fur trapper led her to jump “from a ledge overlooking” the lake.

Written accounts and archaeological finds do something that Native Americans inhabited the Creve Coeur Place from 9500 BC to 1800 AD. French explorers began gardening and fishing in the Place in the to the front 18th century, and fur trappers decided there in the to come 19th century. When the Place was acquired by the United States through the Louisiana Purchase in 1803, the Lewis and Clark Expedition came through Creve Coeur. During the American Civil War, men from the area served upon both sides of the conflict, but most residents were southern sympathizers.

Creve Coeur was incorporated in 1949. Although cabins beyond 200 years old (including two nevertheless in Conway Park) are in the community, it grew primarily as a stopping point along Olive Boulevard (now Route 340) between University City and Creve Coeur Lake. It expanded faster later construction of Interstate 270 and U.S. Route 40.