Commerce is a Mississippi River village in Scott County, Missouri, United States. The population was 67 at the mature of the 2010 census.

In 1788, the present site of Commerce was first occupied by French settlers, making Commerce apparently the third-oldest gift site harmony in Missouri after St Louis and St. Charles. A trading post standard in 1803 served as the middle of commerce for the region, hence the post of the settlement. In 1823, the circuit court ordered a board of commissioners to be appointed to lay out lots here. From 1864 to 1878, Commerce was the county chair of Scott County. Commerce was one of the few areas in Scott County to have uninterrupted mail minister to during the Civil War, as guerilla bands elsewhere made delivery unsafe for the northern carriers. Commerce, along taking into account the German pact of New Hamburg, were the two enclaves of Union sympathizers in Scott County during the war. On November 1, 1861, Colonel Oglesby landed in Commerce later about 3,000 men, where his soldiers soon exchanged shots gone M. Jeff Thompson. On December 29, 1861, Thompson raided Commerce. On February 21, 1862, General Pope landed here in the circulate of 140 troops, but in imitation of he left a week cutting edge his force consisted of 26,153 men. The island in stomach of Commerce was known as Cat Island at least as in advance as Mark Twain’s time; however, it has been absorbed by Powers Island to the south. Commerce was a Methodist town, with a congregation time-honored as ahead of time as 1825 and without a Baptist church until 1906.

Commerce is located at 37°9′26″N 89°26′47″W / 37.15722°N 89.44639°W / 37.15722; -89.44639 (37.157131, -89.446512).

According to the United States Census Bureau, the village has a total Place of 0.35 square miles (0.91 km), all land.