Wesson is a town in Copiah and Lincoln counties, Mississippi, United States. The population was 1,925 at the 2010 census. It is allocation of the Jackson Metropolitan Statistical Area.

The town of Wesson was founded in 1864, during the Civil War, by Col. James Madison Wesson. Having free his mills at Bankston, Wesson relocated to the town that now bears his name. There he built the Mississippi Manufacturing Company which produced a fine quality cotton fabric. In 1871 he sold the mill to William Oliver and John T. Hardy who renamed it the Mississippi Mills.

The mills became famous for the tone of cotton fabric produced which was dubbed “Mississippi silk” at the Centennial celebration of 1876. A product of the Industrial Revolution, the mills in Wesson began to utilize the supplementary technology of the hurriedly changing age. One year after Thomas Edison perfected the buoyant bulb, the Mississippi Mills put them to use. It was said that passengers on the evening train would rush to the windows gone passing through Wesson in order to see the marvelous lights.

This prosperity, however, came to an decline after the death of Captain Oliver in 1891. Financial difficulties followed by the economic Panic of 1893, family conflict, and labor disputes caused the mills to fall into receivership in the to come 1900s. Eventually, the mills were dismantled and sold for scrap during the First World War.