Vancleave is an unincorporated community and census-designated place (CDP) in Jackson County, Mississippi, United States. It is part of the Pascagoula Metropolitan Statistical Area. The population was 5,886 at the 2010 census, up from 4,910 at the 2000 census.

Vancleave occupies a large part of central Jackson County; according to the United States Census Bureau, the CDP has a total area of 44.1 square miles (114.3 km), of which 43.2 square miles (111.8 km²) are estate and 0.97 square miles (2.5 km), or 2.21%, are water. The original hamlet of Vancleave is along Mississippi Highway 57 on high auditorium north of the valley of Bluff Creek. The CDP limits extend north as far away as Mississippi Highway 614 (Wade–Vancleave Road), east to the Pascagoula River and Ward Bayou, and south to the Gautier city stock at the mouth of Bluff Creek. The western boundary is formed mainly by Bluff Creek and Highway 57. Vancleave is 18 miles (29 km) northwest of Pascagoula, the Jackson county seat, and 19 miles (31 km) northeast of Biloxi.

As of the 2020 United States census, there were 5,592 people, 1,785 households, and 1,224 families residing in the CDP.

As of the census of 2000, there were 4,910 people, 1,624 households, and 1,354 families residing in the CDP. The population density was 113.1 people per square mile (43.7/km²). There were 1,764 housing units at an average density of 40.6/sq mi (15.7/km). The racial makeup of the CDP was 91.20% White, 6.74% African American, 0.57% Native American, 0.26% Asian, 0.24% from additional races, and 0.98% from two or more races. Hispanic or Latino of any race were 0.96% of the population.