Quitman is a city in Clarke County, Mississippi, United States, along the Chickasawhay River. The population was 2,323 at the 2010 census. Quitman is the county seat of Clarke County.

Quitman was traditional in 1839 and named as the county seat.

During the Civil War, a hospital built subsequent to funds raised in Galveston and Houston, among further places, was built there for the care of Confederate soldiers from Texas. Originally staffed by Louis Bryan bearing in mind supplies purchased in Mexico, he was joined, and future supplanted, by Enos Bonney, a surgeon from Enterprise, Mississippi, who stayed until the hospital was burned down. Though it cared for troops from any state, the hospital was colloquially known as “The Texas Hospital.” Wounded soldiers from the Second Battle of Corinth, Battle of Iuka, Battle of Jackson, Tennessee, and more local engagements, as competently as those problem from wartime diseases, were treated at the hospital. A cemetery was established adjacent to the hospital for those who succumbed to sickness or wounds.

During General Sherman’s Meridian Campaign, Brigadier General Walter Q. Gresham, Commander of the Third Brigade, Fourth Division, 17th Army Corps, was cold and sent to Quitman to ruin bridges crossing the Chickasawhay river and through Alligator Swamp, as well as any extra infrastructure that could be of any use to the Confederacy. The force arrived at Quitman and proceeded to burn the town jail, courthouse, various stores, the railroad depot, and the Methodist Church, which was instinctive used as a hospital. Troops after that burned down the whole Texas Hospital complex, which included two main buildings as skillfully as twelve to fifteen barracks. The hospital was never rebuilt.