Houston is a city in and one of two county seats of Chickasaw County, in northern Mississippi, United States. The population was 3,623 at the 2010 census.

Native American groups had long used the difficult Chickasaw County for millennia since the coming of European adventurers. Eventually the natives were in fact forced out of the area. An 1832 agreement finally made the area secure for settlement, and emigrants hurriedly moved in. The formation of Chickasaw County was authorized on February 9, 1836, and a few days progressive a committee was authorized to determine the location of the county seat. Judge Joel Pinson offered to donate home for progress of this seat, and on July 8, 1836, his allow was accepted. Pinson named the pact Houston in rave review of Sam Houston, a childhood friend.

Construction began that year on a brick courthouse on the village square, and a jail one block north. The city of Houston was incorporated on May 9, 1837, and its first name office was authorized on December 5 of that same year. This means that Houston, Mississippi actually predates Houston, Texas, because the latter was incorporated one month later, on June 5, 1837.

The Civil War brought widespread ruin and loss to the county, including an incident taking into account Union troops burned nearly all the county’s history as workers tried to disturb them out for safekeeping. During the following decade, the nearly-moribund economy slowly recovered, but destitute roads across the Place continued to hamper commerce and daily life. To habitat this shortcoming, in 1866 the state authorized a second judicial district to be based in Okolona, while allowing the existing facilities in Houston to continue. Thus, the county became one of the few in the nation to host two bases for its court system.