DeLisle is a census-designated place (CDP) in Harrison County, Mississippi, United States. It is share of the Gulfport–Biloxi Metropolitan Statistical Area. The population was 1,147 at the 2010 census.

DeLisle is located at 30°22′44″N 89°16′5″W / 30.37889°N 89.26806°W / 30.37889; -89.26806. It is located on the north side of DeLisle Bayou and the Wolf River, which sever the community from the city of Pass Christian.

According to the United States Census Bureau, the CDP has a total area of 5.3 square miles (13.8 km), of which 5.2 square miles (13.5 km²) is house and 0.12 square miles (0.3 km), or 2.13%, is water.

Pierre Le Moyne d’Iberville was fixed by Louis Phélypeaux, comte de Pontchartrain, Louis XIV’s minister of Marine, to acknowledge a French colony in the area. On d’Iberville’s second vacation to the Gulf in 1699-1700, d’Iberville was accompanied by the accomplished royal cartographer, Compte Guillaume Delisle. During this expedition, they charted and named Bayou Portage, Bayou Arcadia, and Bayou Delisle.
The unincorporated Place north of the bayou, known as DeLisle, shares a zip code in the tell of Pass Christian, Mississippi, but is not within the city limits. The early deal was called La Riviere des Loups (Wolf River). The very old verifiable history for the DeLisle Place show that Barthelome Grelot was followed by his brother-in-law Philipe Saucier, who usual two Spanish land grants; one in the St. Louis Bay area, recorded upon August 27, 1781, followed in 1794, with a second tract that was situated on Bayou DeLisle, adjacent to his brother-in-law, Bartholome Grelot. These ahead of time French settlers were soon allied by Jean Baptiste Nicaise, Pierre Moran, Ramon Lizana, Chevalier DeDeaux, Jean Cassibry, and Charles Ladner.