Belzoni ( bel-ZOHN-ə) is a city in Humphreys County, Mississippi, United States, in the Mississippi Delta region, on the Yazoo River. The population was 2,235 at the 2010 census. It is the county seat of Humphreys County. It was named for the 19th-century Italian archaeologist/explorer Giovanni Battista Belzoni.

The area was named Farm-Raised Catfish Capital of the World in 1976 by then Governor Cliff Finch, since it produces more farm-raised catfish than any new U.S. county. About 40,000 acres (160 km²) of the county are below water in ponds used to grow catfish. About 60% of U.S. farm-raised catfish are grown within a 65-mile (100-km) radius of Belzoni. The title “Catfish Capital” is next claimed by Savannah, Tennessee, Des Allemands, Louisiana, and Selkirk, Manitoba. Belzoni is known for the World Catfish Festival held all April.

The area that eventually became Belzoni was originally known as “Greasy Row” because of saloons along the bank of the Yazoo River, which was the main transportation route until replaced by railroads. In 1895, a charter was granted for the village of Belzoni, although the Place had been contracted by European Americans and African Americans for several decades previously. It was developed for cotton plantations since the Civil War and relied upon agriculture without difficulty into the 20th century. Steve Castleman, who secured the charter, was elected as the first mayor of Belzoni. When Humphreys County was formed by the give leave to enter legislature in 1918, Belzoni was selected as the county seat.

Belzoni was the site of the murder of an at the forefront civil rights pioneer. The Rev. George W. Lee, an African American minister who was seeking voting rights for the disenfranchised blacks of the Mississippi Delta and registered to vote, was murdered in 1955 in “Bloody Belzoni” by white residents working to confirmation segregation. His killers were never found, as the executive of Mississippi, Hugh L. White, refused to question the case. Many judge Lee the first martyr of the ahead of its time civil rights movement.