Perryville is a town in Cecil County, Maryland, United States. The population was 4,361 at the 2010 census. The town is located close an access for Interstate 95, on the north side of the outlet of the Susquehanna River.

Perryville was first established by Europeans in 1622, when Edward Palmer was granted a patent for a settlement upon what is now Garrett Island. During the 17th century, Lord Baltimore arranged George Talbot 31,000 acres (130 km) of land, which included the Perryville area. Before incorporation (1882), the treaty was known as Lower Ferry (circa 1695), Susquehanna (circa 18th century), and was finally named Perryville after Mary Perry, the wife of John Bateman.^[who?]

During the Revolutionary War, Perryville served as a staging Place for the Continental Army. Colonel John Rodgers (1728–1791), who operated the ferry and tavern in Perryville, raised the 5th Company of the Maryland Militia. This company became ration of the well-known Flying Camp and was instrumental during the forward stages of the Revolutionary War. George Washington stopped frequently at Rodgers Tavern on his travels from Virginia to New York. Rodgers Tavern was listed on the National Register of Historic Places during 1972. Colonel Rodgers’ son, John Rodgers, was instrumental in suppressing the Tripolitan pirates in the Mediterranean Sea and was in imitation of promoted to Commodore of the Mediterranean Squadron. Commodore Rodgers served as soon as distinction during the War of 1812 and is known as the “Father of the American Navy.”

During the 19th century, Perryville was the midway station for the Wilmington to Baltimore Rail Line. During the American Civil War, the railway line with Perryville and Baltimore was destroyed. To transport troops and munitions to Annapolis, the Union Army another time began the operation of the ferry across the Susquehanna. The Principio Furnace is located friendly and was listed upon the National Register of Historic Places in 1972.