Irvine is a home rule-class city in Estill County, Kentucky, in the United States. It is the seat of its county. Its population was 2,715 at the era of the 2010 census.

Irvine is located in the middle of Estill County at 37°41′49″N 83°58′1″W / 37.69694°N 83.96694°W / 37.69694; -83.96694 (37.696835, -83.966895). The city limits are upon the northeast side of the Kentucky River, and the city is bordered by Ravenna to the southeast. According to the United States Census Bureau, Irvine has a total area of 1.49 square miles (3.85 km²), of which 1.41 square miles (3.65 km) is home and 0.077 square miles (0.20 km²), or 5.13%, is water.

Gen. Green Clay acknowledged the town of Irvine upon 20.5 acres (8.3 ha) of his land on January 28, 1812, four years after Estill County was on bad terms from Madison County. It was named for Col. William Irvine, a voyager settler of Madison County. The publish office was normal in 1813, and the city was incorporated by the disclose legislature in 1849.

As of the census of 2000, there were 2,843 people, 1,259 households, and 793 families residing in the city. The population density was 1,871.7/sq mi (722.7/km²). There were 1,409 housing units at an average density of 927.6/sq mi (358.1/km). The racial makeup of the city was 99.26% White, 0.04% African American, 0.21% Native American, 0.04% from new races, and 0.46% from two or more races. Hispanic or Latino of any race were 0.56% of the population.