Brussels is a village in southern Calhoun County, Illinois, United States. The population was 116 at the 2020 census.

Brussels is the headquarters location of the Two Rivers National Wildlife Refuge, which is noted for its population of bald eagles. The refuge is named after the two great rivers that flow together near to Brussels, the Illinois River and the Mississippi River.

Brussels has one studious district, No. 42, which consists of one grade school (Brussels Grade School) and one high school (Brussels High School). The instructor district serves the surrounding communities of Meppen, Golden Eagle, and parts of Batchtown. In adjunct to the public instructor system, Brussels has a parochial grade school, St. Marys. Brussels High School is small and its enrollment usually hovers at concerning 70 students.

Brussels was first approved in 1822, when John Mettz came to the area; later in the similar year, Joshua Twitchell time-honored the community’s first business, a blacksmith shop. In 1843, Brussels’ population grew significantly due to an influx of German immigrants. German immigration continued through the 1860s, and Irish immigrants in addition to began settling in Brussels in the 1850s. The Wittmond Trading Post, one of the first brick stores in the region, opened in Brussels in 1847, marking the introduction of the village’s personal ad development. St. Mary’s Church formed in 1848 to benefits the community’s Catholic residents; its current church building was build up in 1863. In the yet to be 1860s, St. Matthew’s Church formed for Brussels’ German Lutheran population. Brussels opened its own name office in 1875 and built its own jail in 1876. In 1888, Brussels was legally incorporated as a village.