Manchester is a town in Meriwether and Talbot counties in the U.S. state of Georgia, although primarily in Meriwether. The population was 3,584 at the 2020 census, down from 4,230 in 2010. It is the most populous community in Meriwether County. CSX Transportation runs a railroad yard in Manchester.

Manchester was founded in 1907, when the Atlanta, Birmingham and Atlantic Railway was outstretched northward to that point; it was multipart into the Atlantic Coast Line Railroad in 1946. From Manchester the railroad diverged, with one extraction going to Atlanta and other to Birmingham. The Georgia General Assembly incorporated Manchester as a city in 1909. The city was named after Manchester, in England.

In 2019, CSX Transportation demolished the historic Manchester Yard Office in order to make habit for a new, larger, yard facilities building.

Manchester is in west central Georgia, in southern Meriwether County, with a small portion extending south into Talbot County. The ridge of Pine Mountain runs along the southern edge of the city, rising 300 feet (91 m) above the city to an height of 1,180 feet (360 m) above sea level. Georgia State Route 85 is the main highway through the city, leading southwest 39 miles (63 km) to Columbus and north 10 miles (16 km) to Woodbury. Georgia 85 meets Georgia 190 in the southern allowance of the city, which leads west 16 miles (26 km) along the crest of Pine Mountain to U.S. Route 27 south of the town of Pine Mountain. Georgia 85 meets Georgia 41 in the middle of Manchester, which leads southeast 6 miles (10 km) to Woodland and northwest 5 miles (8 km) to Warm Springs.