Hosford is an unincorporated community and census-designated place in Liberty County, Florida, United States. Its population was 650 as of the 2010 census. It is located at the junction of State Road 20 and State Road 65. Hosford has a post office like ZIP Code 32334. It has one school, Hosford Elementary School and Jr. High School, and a public library, Jimmy Weaver Memorial Public Library. Hosford is the site of a Georgia-Pacific mill.

Hosford, Florida was originally known as Coe’s Mill. It was founded in 1859 and was named for the Coe family. One fanatic of the Coe family, Katherine, married Robert Flournoy Hosford. While Robert Flournoy Hosford worked in the Florida make a clean breast senate, he helped to convince the railroad to succeed to Liberty County. In honor of his enactment in bringing the railroad to Liberty County, the town of Coe’s Mill was misrepresented to the town of Hosford.

In 1910, the Hosford Lumber Company filed for bankruptcy. A 1912 article by The Pensacola Journal described Hosford as a “thriving little town.” Graves Saw Mill helped assist the accumulation in Hosford. Visitors to Hosford could stay at the local hotel past electricity and artesian water and visit the local mineral spring. By this time, Hosford already had a local college and local church.

In 1914, Liberty County residents voted 226 to 123 in accord of the county chair being located in Bristol on the other hand of Hosford. Letters patent were issued in July 1916 for the Hosford Coca-Cola Bottling Company, but the charter was forfeited in 1936.