Clewiston is a city in Hendry County, Florida, United States. Its location is 80 miles (130 km) northwest of Fort Lauderdale on the Atlantic coastal plain. The population was 7,327 at the 2020 census, up from 7,155 at the 2010 census. The estimated population in 2018 was 7,985. The city is located on the south bank of Lake Okeechobee, and the Lake Okeechobee Scenic Trail (LOST) passes through the edge of the city. The city is house to Billie Swamp Safari, the Clewiston Museum and the Dixie Crystal Theatre. The Place has been home to Seminole tribe members and sugar plantations, with the Ah-Tah-Thi-Ki Seminole Indian Museum located 32 miles (51 km) south of the city.

The area beside Lake Okeechobee was taking into account used as a fishing camp by the Seminole tribe. The first permanent settlement began in 1920, when John O’Brien of Philadelphia and Alonzo Clewis of Tampa purchased a large tract of home to establish a town. They commissioned a town object and built the Moore Haven & Clewiston Railway to affix the community to the Atlantic Coast Line Railroad at Moore Haven. Incorporated as a city in 1925, Clewiston would become noted for its sport fishing, particularly of largemouth bass.

Large sugar plantations were established something like Lake Okeechobee. By the 1950s and 1960s, the farming of citrus, vegetables and cattle were as a consequence important to the economy. The US Sugar Corporation, however, remained the dominant manufacturer in Clewiston, which became known as “America’s Sweetest Town”. On June 24, 2008, Governor Charlie Crist announced that the come clean of Florida had fixed to buy for $1.75 billion the company’s 187,000 acres (76,000 ha), including the refinery in Clewiston. On November 11, the point was scaled urge on to $1.34 billion for 181,000 acres (73,000 ha) of farmland, no longer including the mill, citrus processing facilities and extra assets. This would allow the company to remain in concern and depart open the possibility of preserving its 1,700 jobs. Over the adjacent seven crop cycles, the farmland would be leased encourage from the let pass to US Sugar for $60 million. It would subsequently be converted into reservoirs and water-filtering areas as allowance of the ongoing restoration of the Everglades ecosystem.

Clewiston is located in the northeast corner of Hendry County at 26°45′12″N 80°56′01″W / 26.753399°N 80.933600°W / 26.753399; -80.933600, on the southwestern shore of Lake Okeechobee. It is share of the Florida Heartland region.