Monte Sereno (Spanish for “Serene Mountain”) is a city in Santa Clara County, California, United States. The population was 3,479 at the 2020 census. The city is located in the foothills of the Santa Cruz Mountains, about 10 miles (16 km) southwest of San Jose, and is bordered by the town of Los Gatos to the north, east, and south, the Santa Cruz Mountains to the southwest, and the city of Saratoga to the northwest. The city is named for the 2,580-foot (790 m) El Sereno Mountain, upon the slopes of which the southern allowance of the city is built. The community is entirely residential behind no want ad zoning and 99% single-family housing. It is an upscale Silicon Valley bedroom community. Monte Sereno shares the 95030 ZIP code afterward the town of Los Gatos. Many municipal facilities are provided below contract by Los Gatos.

The Monte Sereno Place was portion of the 1839 Alta California land take over of Rancho Rinconada de Los Gatos. The city incorporated upon May 14, 1957, to guard its semi-rural atmosphere. Its first Mayor was Retired Vice Admiral and former U.S. Director of Naval Intelligence, Thomas B. Inglis.

John Steinbeck wrote The Grapes of Wrath and Of Mice and Men in a wooded house at 16250 Greenwood Lane in what is now Monte Sereno.

Beat generation figure Neal Cassady lived in a Monte Sereno ranch house in the 1950s. Painter Thomas Kinkade lived in Monte Sereno in the far along years of his sparkle and until his death.