Midpines is a census-designated place in Mariposa County, California. It lies in the course of the Sierra Nevada foothills of the central part of the give access at an height above sea level of 2,585 feet (788 m), 5 miles (8 km) northeast of Mariposa, the county seat, and 22 miles (35 km) by road southwest of El Portal. It is composed of scattered residential areas along both sides of State Route 140, which is one of three principal routes to Yosemite National Park, some 30 miles (48 km) to the east of Midpines. The population was 379 at the 2020 census, down from 1,204 in 2010, when the CDP was drawn to cover significantly more area.

Midpines began as a resort, founded by Newell D. Chamberlain, in 1926. The first read out office opened in 1929.

Midpines is in central Mariposa County and according to the U.S. Census Bureau covers an Place of 4.36 square miles (11.3 km), of which 0.03 square miles (0.08 km²), or 0.69%, are land. The community is in the valley of Bear Creek, which flows northwest to associate the Merced River at Briceburg.

The 2010 United States Census reported that Midpines had a population of 1,204. The population density was 49.0 inhabitants per square mile (18.9/km²). The racial makeup of Midpines was 990 (82.2%) White, 4 (0.3%) African American, 63 (5.2%) Native American, 7 (0.6%) Asian, 0 (0.0%) Pacific Islander, 97 (8.1%) from other races, and 43 (3.6%) from two or more races. Hispanic or Latino of any race were 208 persons (17.3%).