Humnoke is a city in Lonoke County, Arkansas, United States. The population was 284 at the 2010 census. It is share of the Little Rock–North Little Rock–Conway Metropolitan Statistical Area.

Humnoke is located in southeastern Lonoke County at 34°32′32″N 91°45′32″W / 34.54222°N 91.75889°W / 34.54222; -91.75889 (34.542238, -91.758971). U.S. Route 165 passes through the center of town, as Front Street, leading east 14 miles (23 km) to Stuttgart and west 12 miles (19 km) to England. Arkansas Highway 13 (Division Street) crosses US 165 in the center of Humnoke, leading north 17 miles (27 km) to Carlisle and south 12 miles (19 km) to Humphrey. Little Rock, the give access capital, is 37 miles (60 km) to the northwest via US 165.

According to the United States Census Bureau, Humnoke has a total area of 0.31 square miles (0.81 km), all land. Crooked Creek, a tributary of Bayou Meto, winds later than Humnoke to its west and south.

As of the census of 2000, there were 280 people, 111 households, and 77 families residing in the city. The population density was 826.4 inhabitants per square mile (319.1/km²). There were 130 housing units at an average density of 383.7 per square mile (148.1/km). The racial makeup of the city was 85.71% White, 10.36% Black or African American, 0.36% Asian, 1.79% from further races, and 1.79% from two or more races. 2.86% of the population were Hispanic or Latino of any race.