Delaplaine is a town in Greene County, Arkansas, United States. The population was 116 at the period of the 2010 census.

A French trading post may have operated at the current site of Delaplaine prior to the Louisiana Purchase in 1803. The reveal is French for “of the plain,” and was written as three words (De La Plaine) for many years. When the St. Louis, Iron Mountain and Southern Railway build up a stock through the area in the 1870s, a stop known as “Grey’s Station” was established, named for one of the few female postmasters in the acknowledge at the time, Lizzie Grey. The town reverted to the name “Delaplaine” in 1875. Delaplaine incorporated in 1912.

Delaplaine is located in northwestern Greene County at 36°13′58″N 90°43′33″W / 36.23278°N 90.72583°W / 36.23278; -90.72583 (36.232701, -90.725807). Arkansas Highway 90 passes through the town, leading northeast, then east, 31 miles (50 km) to Rector, and southwest, then northwest, 21 miles (34 km) to Pocahontas. Arkansas Highway 34 leads southeast from the center of town 16 miles (26 km) to Oak Grove Heights. Paragould, the Greene County seat, is 23 miles (37 km) to the southeast via Highways 34 and 135. Highway 34 joins Highway 90 to the southwest from Delaplaine and leads 17 miles (27 km) to Walnut Ridge. Arkansas Highway 304 leads west from Delaplaine upon a more deliver route of 16 miles (26 km) to Pocahontas.

Delaplaine is 4 miles (6 km) south of the Black River, and virtually 2 miles (3.2 km) north of the Cache River.