Casa Blanca is a census-designated place (CDP) in Pinal County, Arizona, United States, located in the Gila River Indian Community. The population was 1,388 at the 2010 census.

Casa Blanca, formerly known to the Mexicans as La Tierra Amontonada (The Land Piled Up), named for the Hohokam ruin mound nearby, was one of the Pima Villages on the Gila River in what was then part of the state of Sonora, Mexico. It was encountered by the American expedition of Stephen W. Kearny in 1846 and far ahead by Americans on their showing off to California on the Southern Emigrant Trail during the California Gold Rush. Following the Gadsden Purchase the Pima Villages became share of New Mexico Territory. In 1857, the San Antonio-San Diego Mail Line passed through the village on the showing off between Maricopa Wells and Tucson.

In 1858 subsequently Lieutenant A. B. Chapman, of the 1st Dragoons, took the first census of the Pimas and Maricopas, he found a Pima population of 535; 110 warriors, 425 women and kids led by a Captain named Chelan at this village now named Casa Blanca. The next year another official census was taken by the special Indian Agent that showed Casa Blanca had 491 Pimas, broken by the side of as 50 Aged, 146 Men, 103 Women, 105 Boys, 87 Girls, led by Captain Candela. Also enumerated were 30 cattle and 46 horses. The 1860 Census showed a total Pima population of 323 composed of 71 Male heads of household, 66 Female heads, 82 Male Children 87 female children and 17 Other males and females. It also behave they had 164 horses and 102 cattle and 59 farmers tilled 587 acres of enlarged land.

Casa Blanca became the site of the Casa Blanca Station of the Butterfield Overland Mail in 1858. It was located practically 4,200 feet west-northwest of the Casa Blanca ruin mound.