Wellsburg is a city in and the county chair of Brooke County, West Virginia, United States. The 2020 census recorded a population of 2,455. It is a ration of the Weirton–Steubenville metropolitan area. The city’s economy includes several telemarketing facilities, and a factory that does metal fabrication and plastics molding.

The town was laid out in 1790, and its say office was opened upon September 1, 1870.

In 1772, the Cox brothers, Friend, Israel, and Jonathan, made tomahawk rights claims accumulation 1,200 acres (4.9 km) in the Place now including Wellsburg. In March 1788, Charles Prather purchased 481 acres (1.95 km²) from the Cox heirs for $3,000. In 1791, Prather petitioned Ohio County to incorporate the town of Charlestown, Virginia, naming it after himself. The indigenous name continued until 1816, when it was untouched to Wellsburg, to avoid confusion past Charles Town, Jefferson County. The additional name was in award of Charles Wells (1745-1815), Charles Prather’s son-in-law, builder of the first large flour warehouse in the east. Late in 1890, nearby Midway and Lazearville were annexed to Wellsburg.

Wellsburg was the home of Patrick Gass, the last steadfast member of the Lewis and Clark expedition and author of a memoir of the well-known journey. Here next was the home of Joseph Doddridge, author of Notes on the Settlement and Indian Wars. In 1832, the indigenous Grimes Golden apple tree was found just east of Wellsburg. The first glass factory in Western Virginia was built at Wellsburg in 1813.