Rainelle is a town upon the western edge of Greenbrier County, West Virginia, United States. It sits at the base of Sewell Mountain and Sims Mountain, and is bisected by the Meadow River. The unaided means of transportation to and from Rainelle are roads; primarily US 60 and WV 20, which merge on the western fall of the town, and the James River and Kanawha Turnpike, which enters from the south. The population was 1,190 at the 2020 census.

The valley and community that contain and predates Rainelle is named Sewell Valley after Stephen Sewell, a scout that granted in the Place in the 1750s. The community west of the Meadow River first applied for the name Raine in tribute of the Raine relations but was turned by the side of by the Post Office Department. They adopted the publicize Rainelle in 1909. Thomas W. Raine and his brother John moved to the location from Pennsylvania in 1906 to harvest a large stand of hardwoods for building homes, etc. Their Meadow River Lumber Company operated for 60 years, and at one epoch was the largest hardwood sawmill in the world. In 1970, the owners sold it to Georgia-Pacific Corporation, which tore it alongside in 1975.

The town has suffered from several natural disasters in the last decade: most notable of these have been the June 2012 North American derecho, Hurricane Sandy, and the 2016 West Virginia flood. Rebuilding and demolition of structures damaged in the 2016 flood was yet in evolve in January 2020. Homes rebuilt behind funds from the federal Hazard Mitigation Grant program were required to be sited two feet above the 100-year floodplain.

Rainelle is located at 37°58′11″N 80°46′2″W / 37.96972°N 80.76722°W / 37.96972; -80.76722 (37.969639, -80.767210).