Presidio is a city in Presidio County, Texas, United States. It is situated on the Rio Grande (Río Bravo del Norte) River, on the opposite side of the U.S.–Mexico be stuffy to from Ojinaga, Chihuahua. The name originates from Spanish and means “fortress”. The population was 4,169 at the 2000 census, and had increased to 4,426 as of the 2010 US census.

Presidio is upon the Farm to Market Road 170, and U.S. Route 67, 18 miles (29 km) south of Shafter in Presidio County. Presidio is nearly 250 miles (400 km) southeast of El Paso, 240 miles (390 km) southwest of Odessa, and 145 miles (233 km) northeast of Chihuahua City.

The junction of the Rio Conchos and Rio Grande at Presidio was approved thousands of years ago by hunting and increase peoples. By 1200 CE, the local Native Americans had adopted agriculture and lived in small, closely knit settlements, which the Spaniards sophisticated called pueblos. (See La Junta Indians)

The first Spaniards came to Presidio in 1535 CE, Álvar Núñez Cabeza de Vaca and his three companions stopped at the Native American pueblo, placed a cross upon the mountainside, and called the village La Junta de las Cruces. On December 10, 1582, Antonio de Espejo and his company arrived at the site and called the pueblo San Juan Evangelista. By 1681, the Place of Presidio was known as La Junta de los Ríos, or the Junction of the Rivers. Five Jumano towns were located along the Rio Grande to the north of the junction, consisting largely of long-lasting houses. In 1683, Juan Sabeata, the chief of the Jumano nation, reported having seen a fiery cross upon the mountain at Presidio and requested that a mission be usual at La Junta. The deal in 1684 became known as La Navidad en Las Cruces. The missions La Navidad en las Cruces, San Francisco de los Julimes, San Antonio de los Puliques, Apostol Santiago, and Santa María de la Redonda may have been established upon the Texas side of the Rio Grande at La Junta.