Salem is a U.S. town in Oconee County, South Carolina. The population was 135 at the 2010 United States Census.

Salem is located at 34°53′19″N 82°58′29″W / 34.88861°N 82.97472°W / 34.88861; -82.97472 (34.888599, -82.974666). The town lies in the foothills of the Blue Ridge Mountains along South Carolina Highway 130, just south of its junction in imitation of South Carolina Highway 11. Lake Keowee and Keowee-Toxaway State Park lie just to the east, and Lake Jocassee and Devils Fork State Park lie to the northeast. The North Carolina-South Carolina be unventilated to passes several miles north of Salem.

According to the United States Census Bureau, the town has a total Place of 0.8 square miles (2.2 km), all of it land.

At the 2000 census there were 126 people, 54 households, and 36 families in the town. The population density was 150.5 people per square mile (57.9/km). There were 72 housing units at an average density of 86.0 per square mile (33.1/km²). The racial makeup of the town was 95.24% White, 0.79% African American and 3.97% Native American.
Of the 54 households 31.5% had children under the age of 18 living in imitation of them, 59.3% were married couples busy together, 7.4% had a female householder afterward no husband present, and 33.3% were non-families. 31.5% of households were one person and 22.2% were one person aged 65 or older. The average household size was 2.33 and the average associates size was 2.94.