Sayre is a borough in Bradford County, Pennsylvania, United States. It is allocation of Northeastern Pennsylvania. It is the principal city in the Sayre, PA Micropolitan Statistical Area. It lies 18 miles southeast of Elmira, New York, and 30 miles southwest of Binghamton. It is currently the largest city in Bradford County. In the past, various iron products were made there. In 1900, 5,243 people lived there; in 1910, 6,426 people lived there, and in 1940, 7,569 persons made their homes in Sayre. The population was 5,403 at the 2020 census.

Sayre is allocation of the Penn-York Valley (“The Valley”), a group of four contiguous communities in New York and Pennsylvania: Waverly, New York; South Waverly, Pennsylvania; Sayre; Athens, Pennsylvania, and smaller surrounding communities afterward a combination population close 35,000.

In May 1870, a Waverly banker named Howard Elmer, along past Charles Anthony and James Fritcher, bought the Pine Plains Place between Waverly and Athens. Elmer convinced Asa Packer to locate a new railroad fix facility on the Pine Plains for the expanding Lehigh Valley Railroad, which was making a shove north to link up to the Erie Railroad at Waverly. Robert Heysham Sayre, president of the Pennsylvania and New York Railroad, helped epoxy resin the deal. The town was named in his honor. Sayre was incorporated on January 27, 1891.

In 1904 subsequently the locomotive shops were built at Sayre, the main shop building was believed to be the largest structure in the world below one roof, but held that title for solitary a brief time. The railroad operated from 1870 until 1976, but grant facilities were shifted away past that. With the halt of industry, population has declined in the past 1940.