Weston is a city in Umatilla County, Oregon, United States. It was originally a state office called Mitchell’s Station, established in February 1867. In September 1869, T.T. Lieuallen renamed the read out office after his hometown, Weston, Missouri. The population was 667 at the 2010 census. It is allocation of the Pendleton–Hermiston Micropolitan Statistical Area.

Weston was incorporated by the Oregon Legislative Assembly upon October 19, 1878.

Weston is best known for its relationship with novelist Nard Jones (1904–1972), who lived in the city subsequent to his parents amongst 1919 and 1927, and whose first novel Oregon Detour was set in an Oregon town of 600 inhabitants called “Creston”. When his novel, written according to the tenets of the New Realism moot movement (established years since by Sherwood Anderson, Sinclair Lewis and others) was published in 1930, many of the residents were convinced that his characters were based upon local inhabitants, and considered the play-act a slander adjoining the town. While the legend that Jones was sued and ran out of town for his photograph album is not true, members of the town made an effort to locally suppress permission to the book: copies of the novel were stolen from the local library; after the novel became the subject for a high school student’s folder report, his English scholastic removed the photograph album from both the reading list and the high school library. According to George Venn, local literary historian, even in the 1980s, “trying to figure out or exasperating to recall who the ‘real people’ in the novel is nevertheless a local pastime.”

According to the United States Census Bureau, the city has a total area of 0.68 square miles (1.76 km), all of it land. Weston is located at the foot of the Blue Mountains, on Pine Creek.