Wynona is an incorporated town in central Osage County, Oklahoma, United States. It was founded by a local Osage-Cherokee rancher, Antoine Rogers, in 1903. The population was 437 at the 2010 census, a 17.7 percent end from 531 in 2000.

An Osage-Cherokee rancher, Antoine Rogers, settled in the Place that would become the town of Wynona in 1871, after the Osage tribe had been removed from Kansas to Indian Territory by the U. S. Government. In 1903, the Missouri, Kansas and Texas Railway (also known as the MK&T or Katy railroad) built a stock across Rogers’s land. A gathering was built adjacent to the track, and that situation is considered the introduction of Wynona, which soon became a cattle shipping point.

The Osage Townsite Company began proceed of the town in 1909. By the terminate of the year, the population had grown from 20 to more than 150 residents. The first local newspaper, a weekly named the Wynona Enterprise, appeared in August 1909.

Oil was discovered close Wynona in 1914, and led to the initiation of Wynona Oil and Gas Company. This caused an influx of extra residents to sustain the local oil industry. Wynona’s 1920 census reported 2,749 inhabitants. Wynona remained important for its agriculture and ranching business. Ranchers diversified into producing hogs, poultry and dairy products. However, the town futile to increase electric relieve and paved streets, causing some businessmen to involve elsewhere. The fade away of the boom in Osage County oil production and the onset of the Great Depression caused the population to halt sharply to 1,171 in 1930 and to 652 in 1960. The MK&T solitary its rail line in 1977.