Alexandria is a village in Thayer County, Nebraska, United States. The population was 146 at the 2020 census.

In the 1840s and 1850s, the Oregon Trail passed through present-day Thayer County, following the Little Blue River through southeastern Nebraska before crossing into the valley of the Platte River. Settlers arrived along the trail in the late 1850s. The first remaining white residents of the county arrived in 1858, settling not quite two and a half miles (about four kilometers) south of present-day Alexandria, on the divide amid the Little Blue and immense Sandy Creek. In 1859, Isaac Alexander arrived from Kansas subsequent to a portable gristmill; he arranged on enormous Sandy Creek, where he built a log cabin and stockade.

In 1872, the St. Joseph and Denver Railroad (later the St. Joseph and Grand Island) was Elongated into Thayer County. The railroad passed through the Alexander family’s property. At the railroad’s behest, the Nebraska Land and Town Company platted towns along its route, naming them in alphabetical order; the easternmost of these was Alexandria, followed by Belvidere, Carleton, and Davenport. The town was named after Isaac Alexander’s son, S. J. Alexander, who had been in action in negotiating the railroad’s route through Thayer County, and who unconventional served as Nebraska’s Secretary of State.

Alexandria grew rapidly; its early enlargement was better by residents and businesses upsetting from the town of Meridian, established as the county chair of Jones County (now Jefferson County) but bypassed by the railroad and eventually abandoned. The town supported a flour mill on gigantic Sandy Creek; a newspaper, the Alexandrian, was normal in 1879; and by 1882, there were four churches.