New Madrid (Spanish: Nueva Madrid) is a city in New Madrid County, Missouri, United States. The population was 2,787 at the 2020 census. New Madrid is the county seat of New Madrid County. The city is located 42 miles (68 km) southwest of Cairo, Illinois, and north of an exclave of Fulton County, Kentucky, across the Mississippi River.

The town is upon the north side of the Kentucky Bend in the Mississippi River, which is furthermore known as “New Madrid Bend” or “Madrid Bend.” The river curves in an oxbow not in the distance off from an exclave of Fulton County, Kentucky. Scientists expect the river eventually to clip across the neck of the peninsula and make a more concentrate on channel, leaving the Kentucky territory as an island.

New Madrid was the epicenter of the agreed powerful 1811–12 New Madrid earthquakes.

The first more or less remaining settlement at present-day New Madrid was usual by bands of Shawnee, Delaware, Creek, and Cherokee who were turned into refugees due to the U.S. War for Independence. These refugee Native American bands in style Spanish offers to settle upon the west bank of the Mississippi River in the ahead of time 1780s. These unclean Native American groups normal a concurrence and informal trading pronounce where a northward, horseshoe regulate of the Mississippi met the Chepusa creek, which provided an simple place for landing boats. Native American hunters and European-American merchants made the deal a location for paperwork the bounty of hunts, including the necessary but messy fat of bears and buffalo, which was used in preparing skins and furs. The settlement speedily acquired the pronounce L’Anse a la Graise — “Cove of Grease” or “Greasy Cove.”