Independence, originally known as Uncle Sam, is a town in Tangipahoa Parish, Louisiana, United States. The population was 1,665 at the 2010 census. It is allowance of the Hammond Micropolitan Statistical Area.

The concern to avow Independence as a town was led in the beforehand 20th century by State Representative Harry D. Wilson, who like served from 1916 until his death at the forefront in 1948 as the Louisiana Commissioner of Agriculture and Forestry. Wilson was a son of Dr. and Mrs. William D. Wilson. In 1856, Dr. Wilson had built a buildup in Independence, which remained for years the oldest building in the community. Harry Wilson worked in the parish seat of Amite in the general stock of the merchant Jacob Stern at a time taking into consideration Tangipahoa Parish did not still depend upon the strawberry crop. During the 1890s, Wilson was an spread messenger for the Illinois Central Railroad. He left that approach to pursue a embassy career.

Affectionately known by voters as “Uncle Harry” or “Mister Harry”, Wilson served two nonconsecutive terms in the let in House from 1900 to 1904 and once more from 1908 to 1912. A mighty promoter of his hometown of Independence, located five miles to the south of Amite, Wilson in 1902 and 1903 corresponded bearing in mind Governor William Wright Heard just about incorporation of the community, which at the become old had a population of 308. Governor Heard informed Wilson that he considered the three square miles proposed for the supplementary town as too much home for a small village and suggested that the tract be abbreviated in size. Originally named “Uncle Sam”, Independence had begun in 1852 considering the New Orleans, Jackson and Great Northern Railroad began working through the area. Independence was finally proclaimed a town upon August 22, 1912.

Independence is located at 30°38′7″N 90°30′14″W / 30.63528°N 90.50389°W / 30.63528; -90.50389 (30.635293, -90.504005).