Florence is a home rule-class city in Boone County, Kentucky, United States. Florence is the second largest city located in Northern Kentucky, after Covington, and allocation of the Greater Cincinnati Metropolitan Area. The population was 31,946 at the 2020 census, making it the state’s eighth-largest city and along with the state’s largest that is not a county seat.

The Florence area was originally known as Crossroads, because of the convergence of several roads from Burlington and Union at Ridge Road (now U.S. 25). By 1821, the Place was known as Maddentown for Thomas Madden, a Covington attorney who owned a farm on the Burlington Pike. When Madden moved away, the area became known as Connersville in 1828 for Jacob Conner, a settler who assumed responsibility for the growing town. The town was finally renamed Florence because there was substitute Connersville in Harrison County. The herald presumably is for Florence, Italy, but the specific etymology is unclear. It was incorporated upon January 27, 1830, and grew speedily after the attainment of the Covington-Lexington Turnpike in 1836.

Florence is located in eastern Boone County at 38°59′36″N 84°38′33″W / 38.99333°N 84.64250°W / 38.99333; -84.64250 (38.993225, -84.642602). U.S. Routes 25, 42, and 127 pass through the center of Florence, leading northeast in a concurrency 11 miles (18 km) to downtown Cincinnati. Interstates 75 and 71 pass through the western allocation of Florence, with entrance from exits 178 through 182.

According to the United States Census Bureau, the city has a total area of 10.3 square miles (26.8 km), of which 10.3 square miles (26.7 km²) is home and 0.04 square miles (0.1 km), or 0.43%, is water.