Rancho Murieta is a census-designated place (CDP) and guard-gated community in Sacramento County, California, United States. It is ration of the Sacramento–Arden-Arcade–Roseville Metropolitan Statistical Area. The population was 5,488 at the 2010 census, up from 4,193 at the 2000 census. It is located in the foothills of the Sierra Nevada range, about 25 miles (40 km) east of Sacramento.

According to the United States Census Bureau, the CDP has a total area of 12.1 square miles (31 km), of which, 11.9 square miles (31 km²) of it is land and 0.2 square miles (0.52 km) of it (1.50%) is water. The principal east–west entrance route is California State Highway 16, the Jackson Highway, which connects Rancho Murieta taking into account the Sacramento metropolitan area, to its west and to Amador County and the world well-known Shenandoah wine regions to the east.

The 2010 United States Census reported that Rancho Murieta had a population of 5,488. The population density was 454.8 inhabitants per square mile (175.6/km²). The racial makeup of Rancho Murieta was 4,874 (88.8%) White, 130 (2.4%) African American, 33 (0.6%) Native American, 158 (2.9%) Asian, 6 (0.1%) Pacific Islander, 81 (1.5%) from other races, and 206 (3.8%) from two or more races. Hispanic or Latino of any race were 425 persons (7.7%).

The Census reported that 5,488 people (100% of the population) lived in households, 0 (0%) lived in non-institutionalized society quarters, and 0 (0%) were institutionalized.